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Copyrights 1995-2007 Created and maintained by MBC

 

MEDICSINDEX

 

 

 
 

 

 

 

 
     
 

Dima A. Sabbah, B. Pharm., M.S., Ph.D.

 

986025 Nebraska Medical Center, Omaha, Nebraska, 68198-6028

 

University of Nebraska Medical Center, College of Pharmacy, Department of Pharmaceutical Sciences

Tel: 402-408-2837(home)

 

Email: dima_sabbah@yahoo.com

 

Employment Status

 

F1-OPT (29 months) eligible for an additional 17 months.

 

Professional Experience

 

 

I  look  for  a  research  and  development  position  in  the  pharmaceutical  industry  that  takes  the

 

advantages of extensive experience in computational chemistry and drug design.

 

 

Graduate Research Assistant, Aug 2007- June 2012, University of Nebraska Medical

 

Center

 

·         Homology modeling of phosphoinositide -3- kinases (PI3Ks) using MOE

 

·         Pharmacophore Generation for PI3Kα selective inhibitors using MOE

 

·         Pharmacophore Search against the National Cancer Institute database using MOE

 

·         Molecular Dynamic simulations for the kinase domains of PI3Ks using the AMBER 10 package

 

·         Calculating the binding free energies of prospective inhibitors using the MM/GBSA (molecular mechanics/ generalized born surface area) method in AMBER10

 

·         Recruiting the computational alanine- scanning approach to calculate the relative change in free energy of binding (ΔΔ G bind) for the alanine mutants of binding residues in the protein using MM/GBSA in AMBER10

 

·         Docking studies for PI3K inhibitors using Glide dock in MAESTRO

 

·         Design and Synthesis of novel PI3Kα inhibitors

 

·         Molecular Dynamic simulations for 16 models of β-secretase protein using the AMBER 10 package

 

 

Lecturer, 2004 - 2007, College of Pharmacy, AL-Zaytoonah Private University of Jordan, Amman, Jordan

 

 

· General Chemistry, Pharmaceutical Organic Chemistry, Pharmaceutical Analytical Chemistry, Pharmaceutical Medicinal Chemistry II, Pharmaceutical Medicinal Chemistry I lab, Pharmaceutical Analytical Chemistry Lab, Phytochemistry Lab, Pharmaceutics I Lab, Pharmaceutical Physical Lab I, Microbiology, Microbiology Lab, Parasitology Lab, Pharmaceutical Microbiology Lab.

 

Teaching Assistant, 1996 – 2004, College of Pharmacy, AL-Zaytoonah Private University of Jordan, Amman, Jordan

 

 

·         Pharmacognosy Lab, Phytochemistry Lab, Pharmaceutical Organic Chemistry Lab, Pharmaceutical Analytical Chemistry Lab, Pharmaceutical Medicinal Chemistry Lab, Pharmaceutical Microbiology Lab, Pharmaceutical Biochemistry Lab.

 

Technical Skills

 

·         Molecular Modeling Software (MOE, MAESTRO , PYMOL and AMBER)

 

·         Computer Skills in MS Word, MS Excel, Power Point, and basic Internet Skills

 

·         Chemical : Nuclear Magnetic Resonance Spectroscopy, Gas Chromatography Mass Spectroscopy

 

Education

 

2007-2012

Ph.D. in Pharmaceutical Sciences, University of Nebraska Medical Center

 

(UNMC), NE, USA. Thesis Supervisors: Profs. Jonathan L. Vennerstrom

 

and Haizhen Zhong. Thesis Title: Computational Studies and Inhibitors Design

 

of PI3Kα.

2009-2011

Side Project: Modeling the protonation states of β-secretase Binding Pocket.

2001-2003

M.S. in Pharmaceutical Sciences, University of Jordan (UJ), Amman Jordan.

 

Thesis Supervisor: Professor Ali M. Qaisi. Thesis Title: Synthesis of Some

 

Novel Nitrofuran Derivatives of Potential of Potential Antimicrobial Activity.

June 1996

Bachelor of Pharmacy, University of Jordan (UJ), Amman Jordan.

 

 


 

Peer Reviewed Abstracts (10 Published Abstracts)

 

 

1.    The 44th annual PGSRM, June 7th-9th, 2012, University of Nebraska Medical Center, Omaha, Nebraska. Poster Presentation: Structure-based drug design, synthesis, and

 

biological evaluation of a novel scaffold for PI3kα inhibitors.

 

2.    The Nebraska Academy of Sciences, April 20th, 2012, Lincoln, Nebraska. Oral Presentation: Synthesis, biological evaluation, and molecular docking studies of novel

 

phosphoinositide-3-kinase (PI3kα) inhibitors

 

3.    ACS Denver National Meeting, August 28th- September 1st, 2011. Poster Presentation: Investigation of phosphoinositide 3-kinases binding pocket using mm-pbsa

 

4.    TeraGrid '11, July 18th-21st, 2011, Salt Lake City, Utah. Poster Presentation: Modeling of PI3K using Molecular Dynamic Simulations on UNL Cluster

 

5.    The Nebraska Academy of Sciences, April 15th, 2011, Lincoln, Nebraska. Oral Presentation: Determination of β-secretase binding site charge employing MD simulation and molecular docking

 

6.    ACS Anaheim National Meeting, March 27th-30th, 2011. Poster Presentation: Discovery of Novel Inhibitors of Phosphoinositide-3-Kinases

 

7.    The 45th Midwest Regional Meeting of the ACS, October 27th-30th, 2010.Poster Presentation: Pharmacophore Model, Database Search, Docking Study and Biological Assays for Novel PI3Kα Inhibitors

 

8.    AAPS Graduate Student Symposium in Drug Design and Discovery, November 8th-12th, 2009. Oral and Poster Presentations: Selectivity Studies of PI3K Inhibitors by Molecular Docking. This work is honored by the AAPS. “Graduate Student Symposium Award in Drug Design & Discovery”

 

9.    The Nebraska Academy of Sciences, April 17th, 2009, Lincoln, Nebraska. Oral Presentation: Homology Modeling and Docking Studies of PI3Kα/γ

 

10.  The  43  rd   ACS  Midwest  Regional  Meeting,  October  8th-11th,  2008.  Oral  Presentation: Computational Studies and Inhibitors Design of PI3Kα

 

 

Invited Speaker

 

 

 

1.      Chemistry Department, University of Nebraska at Omaha, November 8, 2010. Oral Presentation: Discovery of Novel Inhibitors of Phosphoinositide 3-Kinases

 

2.      Chemistry Department, University of Nebraska at Omaha, October 5, 2009. Oral Presentation: Selectivity Studies of PI3K Inhibitors by Molecular Docking

 

Peer    Reviewed    Scientific    Articles    (6    Submitted/Accepted/Published    Peer    Reviewed Articles)

 

1.    Sabbah   D.A.,   Vennerstrom   J.L.,   Zhong   H.   Binding   Selectivity   Studies   of

 

Phosphoinositide  3-Kinases  Using  MM-GBSA.  J.  Chem.  Inf.  Model.  2012,  52,

 

3213−3224.

 

2.      Sabbah D.A., Simms N.A., Dong, Y., Ezell, E.L., Brattain M.G., Vennerstrom J.L., Zhong H. N-phenyl-4-hydroxy-2-quinolone-3-carboxamides as selective inhibitors of mutant H1047R phosphoinositide-3-kinase (PI3Kα). Bioorg. Med. Chem. 2012, 20, 7175–7183.

 

3.      Sabbah D.A., Simms N.A., Brattain M.G., Vennerstrom J.L., Zhong H. Biological evaluation and docking studies of recently identified inhibitors of phosphoinositide-3-kinases. J. Bioorg. Med. Chem.2012, 22, 876-880.

 

4.      Sabbah D.A., Brattain M.G., Zhong H. Dual Inhibitors of PI3K/mTOR or MTOR-Selective Inhibitors: Which way Shall We Go? J. Current Medicinal Chemistry 2011, 18, 5528-5544.

 

5.      Sabbah D.A., Vennerstrom J.L., Zhong H. Docking Studies on Isoform-Specific Inhibition of Phosphoinositide-3-Kinases. J. Chem. Inf. Model. 2010, 50, 1887-1898.

 

6.      Sabbah D.A., Vennerstrom J.L., Zhong H. Modeling the Protonation States of β-secretase Binding pocket. (to be submitted)

 

 

Invited Peer Reviewed Book Chapters (1 in revision)

 

1. Chapter in a book: Drug Design and Discovery Targeting Phosphatidylinositol-3-kinases. The book name is: Practical Applications in Structure-Based Drug Design book. (In revision).

 

Awards

 

·         2012   ADDF Young Investigator Scholarship

 

·         2011 COMP’s Denver National Meeting Brochure Cover Image Contest

 

·         2011 Open Science Grid Summer School and TeraGrid '11 Conference Attendance

 

·         2009 AAPS Graduate Student Symposium Award in Drug Design & Discovery

 

 

GRADUATE ASSISTANTSHIPS & FELLOWSHIPS

 

 

·         2010-2012: Bukey Fellowship

 

·         2007-2012: Graduate Studies Research Assistantship

 

 

AFFLIATIONS

 

 

·         American Chemical Society

 

·         American Association of Pharmaceutical Scientists

 

·         US National Association of Professional Women

 

·         Jordan Pharmaceutical Association

 

 

REFERENCES

 

 

 

·         Professor Jonathan Vennerstrom, University of Nebraska Medical Center, College of pharmacy, office phone number: 402 559 5362, email:  jvenners@unmc.edu, address: 986025 Nebraska Medical Center, Omaha, NE 68198-6025, USA

 

·         Professor Edward Roche, University of Nebraska Medical Center, College of pharmacy, office phone number: 402 559 4645, email:  eroche@unmc.edu, address: 986025 Nebraska Medical Center, Omaha, NE 68198-6025, USA

 

 

  • · Professor Haizhen Zhong, University of Nebraska at Omaha, Chemistry Department, office phone number: 402 554 3145, email:  hzhong@unomaha.edu, address: 6001 Dodge Street, Omaha, NE 68182, USA